G-{d-Arg}-GDSP_product_DataBase

Bioactivity	G-{d-Arg}-GDSP is an RGD peptide analogue that binds to the adhesion receptor of integrins and inhibits cellular fibronectin attachment as well as osteoclast resorption[1].
Invitro	G-{d-Arg}-GDSP (17-850 μM, 10 days) significantly inhibits osteoclastic resorption at 170 μM in 17-day-old fetal mouse metacarpals and inhibits 45Ca release in osteoclast precursor-dependent bone organ culture[1]. G-{d-Arg}-GDSP (170 μM, 4 days) shows inhibition of anchorage of periosteal TRAP+ precursors to the mineralized matrix and subsequent osteoclast formation compared with the control group[1].
Name	G-{d-Arg}-GDSP
CAS	111844-21-4
Shortening	G-{d-Arg}-GDSP
Formula	C22H37N9O10
Molar Mass	587.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. G van der Pluijm, et al. Integrins and osteoclastic resorption in three bone organ cultures: differential sensitivity to synthetic Arg-Gly-Asp peptides during osteoclast formation. J Bone Miner Res. 1994 Jul;9(7):1021-8.

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